Platelets are responsible for the accumulation of β-amyloid in blood clots inside and around blood vessels in mouse brain after thrombosis
Year: 2016
Type: article
Abstract: INTRODUCTION: Platelets contain beta-amyloid precursor protein (APP) as well as Aβ peptide (Aβ) that can be released upon activation. During thrombosis, platelets are concentrated in clots and activated. METHODS: We used in vivo fluorescent analysis and electron microscopy in mice to determine to what degree platelets are concentrated in clots. We used immunostaining to visualize Aβ after photothrombosis in mouse brains. RESULTS: Both in vivo results and electron microscopy revealed that platelets were 300-500 times more concentrated in clots than in non-clotted blood. After thrombosis in control mice, but not in thrombocytopenic animals, Aβ immunofluorescence was present inside blood vessels in the visual cortex and around capillaries in the entorhinal cortex. CONCLUSION: The increased concentration of platelets allows enhanced release of Aβ during thrombosis, suggesting an additional source of Aβ in the brains of Alzheimer's patients that may arise if frequent micro-thrombosis events occur in their brains.
Source: Brain Research Bulletin
Authors: Lilia Y. Kucheryavykh, Josué Dávila-Rodríguez, David E. Rivera-Aponte, Lidia V. Zueva, A.Valance Washington, Priscilla Sanabria, Mikhail Y. Inyushin
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,280
Awards: Glial uptake of dopamine after L-DOPA medication, Preparing Future Faculty: RISEing to the Challenge, Microglia promote dispersal of glioma cells through Pyk2 intracellular signaling, UNIVERSIDAD CENTRAL DEL CARIBE BIOMEDICAL RESEARCH CENTERS, Translation Studie of the Planet Specific Receptor Trem Like Transcript (TLT)
OpenAlex ID: W2559272093