A histopathological and magnetic resonance imaging assessment of myelocortical multiple sclerosis: A new pathological variant
Year: 2016
Type: article
Study design: Observational Study
Abstract: Characterization of Spinal Cord, Cortical and Deep Gray Matter Lesions in the Absence of White Matter Lesions……………………………………………..79 Characterization of Spinal Cord Demyelination of Classical and Myelocortical MS Patients…………………………………………………………………….81 Characterization of Cortical Demyelination of Classical and Myelocortical MS Patients………………………………………………..……………………….84Characterization of Demyelination and association with meningeal inflammation on Hemispheric Sections………………………………………………………88 Characterization of Hippocampal Lesions in Classical and Myelocortical MS Patients………………………………………………..……………………….89Characterization of Thalamic Lesions of Classical and Myelocortical MS Patients………………………………………………..……………………….91 Identification of Lesions in the Brainstem of Classical and Myelocortical MS Patients………………………………………………..……………………….92Summary of Histological examination of CNS of Classical and Myelocortical MS Patients………………………………………………..……………………….93Pathology Underlying Magnetic Resonance Imaging Abnormal Signals in Myelocortical MS Patients…………………………………………………….94 MRI-Defined Normal Appearing White Matter in Myelocortical MS………..95 MRI-Defined T2-Only Regions in Myelocortical MS………………………...96 MRI-Defined T2T1MTR Regions in Myelocortical MS………………….…..97 Atrophy and White Matter Lesion Volumes by MRI………………………..104 Comparing Whole Brain Atrophy Between Controls, Classical and Myelocortical MS…………………………………………………………………………….106 V. Conclusions and Discussion………………………………………………......110 Summary of Major Findings………………………………………………….110 Conclusions…………………………………………………………………...112 Importance of the Studies in Management of MS……....…………………….120Impact Statement…………………………………………………………...…128 Limitations of the Thesis…………………………………………….………..129 Recommendations for Future Research………………………………………131 Removal of Inhibitors of Remyelination…………………………………..…131 Mechanism of Cortical Demyelination…………………………………..…..145 Closing Remarks……………………………………………………………..
Author: Megan Vignos
Institution: Kent State University
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2559744184