Bmi1 plays an important role in dentin and mandible homeostasis by maintaining redox balance.
Year: 2016
Type: article
Abstract: mice compared with those from wild-type mice; alterations of these antioxidative enzyme activities, DNA damage markers, cell proliferation and cell cycle-related parameters were all partially rescued by the treatment with antioxidant NAC in Bmi1 deficient mice. These results demonstrated that Bmi1 deficiency resulted in defects in dentin and alveolar bone formation, while the treatment with antioxidant could improve these defects obviously. Therefore, our results indicate that Bmi1 plays an important role in stimulating dentin formation and alveolar bone formation by maintaining redox homeostasis, preventing DNA damage and inhibiting cyclin-dependent kinase inhibitors.
Source: PubMed Central
Authors: Ying Yin, Xian Xue, Qian Wang, Ning Chen, Dengshun Miao
Institutions: Nanjing University, Nanjing Medical University, Jiangsu University
Language: English
Subfield: General Dentistry
Field: Dentistry
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2559804998