Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate
Year: 2016
Type: article
Abstract: Significance Distinct transcription factors regulate the development of immune cell lineages, and changes in their expression can alter the balance of cell types responding to infection. Recent studies have identified Zeb2 as a transcription factor important for the final maturation of natural killer cells and effector CD8 + T cells. In this study, we show that Zeb2 is required for the development of two myeloid cell types, the monocyte and the plasmacytoid dendritic cell, and clarify that this factor is not required for the development of classical dendritic cells.
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funders: Howard Hughes Medical Institute, Burroughs Wellcome Fund, American Heart Association, National Institutes of Health, Japan Society for the Promotion of Science, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences
Awards: The role of SIP1, the causative gene for Mowat-Wilson syndrome, in structural and functional development of brain, Deciphering CD8 Dendritic Cell Development for the Improvement of Vaccine, G5219392223, Washington University Institute of Clinical and Translational Sciences, METABOLIC CONTROL OF TISSUE SPECIFIC MACROPHAGE DIFFERENTIATION, Cancer Center Support Grant
OpenAlex ID: W2560238409