Year: 2016
Type: article
Abstract: Arterial dysfunction has been linked to decline in cardiac function and increased risk of cardiovascular disease events. We calculated the value of arterial function, measured at baseline (2000–2002), in predicting time to first coronary heart disease (CHD) event (median follow-up, 10.2 years) among participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Measures included the following: C1 and C2, derived from diastolic pulse contour analysis from the radial artery blood pressure waveform obtained by tonometry (n = 6,336); carotid distensibility and Young's elastic modulus at the carotid artery, derived from carotid artery ultrasonography (n = 6,531 and 6,528); and aortic distensibility, measured using cardiac magnetic resonance imaging (n = 3,677). After adjustment, the hazard ratio for a CHD event per standard-deviation increment in arterial function was 0.97 (95% confidence interval (CI): 0.86, 1.10) for C1, 0.73 (95% CI: 0.63, 0.86) for C2, 0.98 (95% CI: 0.86, 1.11) for carotid distensibility, 0.99 (95% CI: 0.90, 1.09) for Young's modulus, and 0.90 (95% CI: 0.74, 1.10) for aortic distensibility. We examined the area under the receiver operating characteristic curve for the model with full adjustment plus the addition of each measure individually. C2 provided additional discrimination for the prediction of CHD (area under the curve = 0.736 vs. 0.743; P = 0.04). Lower C2 was associated with a higher risk of future CHD events.
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kww113
Institutions: University of Washington, University of Minnesota, National Institutes of Health, Tufts University, University of California, San Francisco, Northwestern University, Colorado State University, Johns Hopkins University, Université Pierre-et-Marie-Curie, Wake Forest University, University of Wisconsin–Madison
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1261793039, MESA, G1276754516, G1640378483, G1686417863, G21105524, G2144938473, G22458031, G2262782284, MESA, MESA, G2837638605, G290884426, G291913881, G3259655001, G3546712286, G3647016462, G3687594596, MESA, G399481048, TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), G4512137732, OPTION 3. 4/1/2014 - 3/31/2015. MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - READING CENTER, NHLBI, MESA, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, G5787256936, Environmental Factors in Cardiovascular Disease, G6095866717, G6212299381, G6359107525, Institute for Clinical and Translational Research, MESA, G6514094751, Arterial Elasticity, Subclinical, and Clinical CVD in MESA, G66341962, MESA, G78770644, Biostatistics, Epidemiologic, and Bioinformatic Training in Environmental Health (BEBTEH), G94668252
OpenAlex ID: W2560299119