Investigating Simulated Driving Behaviour and Brain Activation in Mild Cognitive Impairment
Year: 2016
Type: dissertation
Study design: Observational Study
Abstract: There are no guidelines or tools to help physicians assess the driving safety of patients with MCI. This study combined fMRI and driving simulation to compare the driving performance, and corresponding brain activation patterns, of patients with MCI and healthy controls. Patients with MCI committed significantly more driving errors compared to controls. Patients with amnestic multiple-domain MCI patients were at a greater risk of difficulty relative to those with amnestic single-domain MCI. Patients with MCI exhibited increased recruitment of frontal brain regions compared to controls, particularly during left turns with traffic. Patients with sd-MCI exhibited increased recruitment of frontal and medial regions across turning conditions, whereas patients with md-MCI exhibited decreased recruitment of frontal and medial regions. The results suggest that patients with MCI can demonstrate driving difficulties and deviations in brain activation compared to controls and that the areas and degree of difficulty vary across the subtypes of MCI.
Source: TSpace (University of Toronto)
Author: Megan A. Hird
Language: English
Topic: Older Adults Driving Studies
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2560525839