Breastfeeding associated with higher lung function in African American youths with asthma
Year: 2016
Type: article
Abstract: Objective: In the United States, Puerto Ricans and African Americans have lower prevalence of breastfeeding and worse clinical outcomes for asthma compared with other racial/ethnic groups. We hypothesize that the history of breastfeeding is associated with increased forced expiratory volume in 1 second (FEV1) % predicted and reduced asthma exacerbations in Latino and African American youths with asthma. Methods: As part of the Genes-environments & Admixture in Latino Americans (GALA II) Study and the Study of African Americans, asthma, Genes & Environments (SAGE II), we conducted case-only analyses in children and adolescents aged 8–21 years with asthma from four different racial/ethnic groups: African Americans (n = 426), Mexican Americans (n = 424), mixed/other Latinos (n = 255), and Puerto Ricans (n = 629). We investigated the association between any breastfeeding in infancy and FEV1% predicted using multivariable linear regression; Poisson regression was used to determine the association between breastfeeding and asthma exacerbations. Results: Prevalence of breastfeeding was lower in African Americans (59.4%) and Puerto Ricans (54.9%) compared to Mexican Americans (76.2%) and mixed/other Latinos (66.9%; p < 0.001). After adjusting for covariates, breastfeeding was associated with a 3.58% point increase in FEV1% predicted (p = 0.01) and a 21% reduction in asthma exacerbations (p = 0.03) in African Americans only. Conclusion: Breastfeeding was associated with higher FEV1% predicted in asthma and reduced number of asthma exacerbations in African American youths, calling attention to continued support for breastfeeding.
Source: Journal of Asthma
Authors: Sam S. Oh, Randal Du, Andrew M. Zeiger, Meghan E. McGarry, Donglei Hu, Neeta Thakur, Maria Pino-Yanes, Joshua M. Galanter, Celeste Eng, Katherine Keiko Nishimura, Scott Huntsman, Harold J. Farber, Kelley Meade, Pedro Avila, Denise Serebrisky, Kirsten Bibbins-Domingo, Michael A. Lenoir, Jean G. Ford, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Shannon M. Thyne, Saunak Sen, Jose R. Rodriguez-Santana, Keoki Williams, Rajesh Kumar, Esteban G. Burchard
Institutions: University of California, San Francisco, Hospital Universitario Nuestra Señora de Candelaria, Baylor College of Medicine, Texas Children's Hospital, UCSF Benioff Children's Hospital, Northwestern University, Jacobi Medical Center, Johns Hopkins University, Kaiser Permanente Vallejo Medical Center, VA Caribbean Healthcare System, University of California, Los Angeles, Centro de Neumologia Pediatrica, Henry Ford Health
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Environmental Health Sciences, National Center for Research Resources, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities
Awards: Genetics of Asthma In Latino Americans, G1217462604, G1268573537, G1314613728, Addressing disparities in chronic disease with a teen and young adult focus, G3211455882, G3301471041, G3429567754, G386207446, Wood Smoke and Genetic Susceptibility to Asthma in An Honduran Population, G4357310183, G454726209, G457392980, Mechanism of Endotoxin's Effect On Allergy Risk, Postdoctoral training in tobacco control, PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMA, Clinical and Transtional Science Institute, Immune-driven Airway Epithelial Dysfunction in Muco-obstructive Asthma, G956528967
OpenAlex ID: W2560577272