Association of Weight Loss Maintenance and Weight Regain on 4-Year Changes in CVD Risk Factors: the Action for Health in Diabetes (Look AHEAD) Clinical Trial
Year: 2016
Type: article
Abstract: OBJECTIVE: Short-term weight loss improves cardiovascular disease (CVD) risk factors. We sought to determine the longer-term effects of maintaining weight loss or, conversely, regaining weight. RESEARCH DESIGN AND METHODS: We used data from Action for Health in Diabetes (Look AHEAD), a randomized trial of intensive lifestyle intervention (ILI) compared to a control condition in overweight/obese individuals with type 2 diabetes. ILI participants were grouped according to weight change patterns, as follows: 1) no weight loss (±3% at years 1 and 4); 2) moderate weight loss (3-8% at years 1 and 4); 3) large weight loss (8-20% at years 1 and 4); 4) moderate loss/full regain (3-8% at year 1/±3% at year 4); 5) large loss/full regain (8-20% at year 1/± 3% year 4); and 6) large loss/partial regain (8-20% at year 1/3-8% at year 4) and changes in CVD risk factors were compared. RESULTS: Adjusting for baseline differences and medication use, larger weight losses produced greater improvements in HbA1c, systolic blood pressure, HDL cholesterol, and triglycerides at years 1 and 4 (all P ≤ 0.02). Despite maintenance of weight loss, HbA1c levels worsened between years 1 and 4, and remained below baseline only in those with large weight losses. We found no negative associations of losing and regaining weight relative to not having lost weight. Moreover, those who had large initial weight loss but full regain of weight had greater improvements in HbA1c levels at year 4 than those with smaller or no initial weight loss. CONCLUSIONS: Larger initial weight loss should be encouraged in individuals with type 2 diabetes, despite the possibility of regain.
Source: Diabetes Care
DOI: 10.2337/dc16-0509
Author: The Action for Health in Diabetes (Look AHEAD) Study Group
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1825392443, General Clinical Research Center, Action for Health in Diabetes Continuation (Look AHEAD-E), 05/16 Action for Health in Diabetes Extension Study - Research Project, 10/16 Action for Health in Diabetes Extension Study Research Project, General Clinical Research Center, 14/16 Action for Health in Diabetes Extension Study Research Project, 02/16 Action for Health in Diabetes Extension Study Research Study, General Clinical Research Center, General Clinical Research Center, GENERAL CLINICAL RESEARCH CENTER, University of Pittsburgh Clinical and Translational Science Institute, 16/16 Action for Health in Diabetes Extension Study Biostatistics Research Center, 09/16 Action for Health in Diabetes Extension Study Research Project, 08/16 Action for Health in Diabetes Extension Study Research Project, 07/16 Action for Health in Diabetes Extension Study Research Project, 04/16 Action for Health in Diabetes Extension Study Research Project, 03/16 Action for Health in Diabetes Extension Study Research Project, G66933475, 13/16 Action for Health in Diabetes Extension Study Research Project, 11/16 Action for Health in Diabetes Extension Study Research Project, Exercise as a Buffer Against Stressed-Induced Eating, 15/16 Action for Health in Diabetes Extension Study Research Project, G7641880336, Obesity/Nutrition Research Center, 12/16 Action for Health in Diabetes Extension Study Research Project, 06/16 Action for Health in Diabetes Extension Study Research Project, Colorado Nutrition Obesity Research Center, G955307958
OpenAlex ID: W2560962203