Work

Biodegradable porous silk microtubes for tissue vascularization

Year: 2016

Type: article

Abstract: vascular endothelial cell attachment and metabolic activity. After 14 days all tubes supported the proliferation of cells and cell attachment increased with porosity. The silk tubes with PEO had similar crystallinity but higher elastic modulus compared with the systems without PEO. The silk (13%)/PEO (1%) system showed the highest porosity (20 μm pore diameters on average), highest cell attachment and fastest degradation profile. There was a good correlation between these parameters with silk concentration and the presence of PEO. The results demonstrate the ability to generate versatile and tunable tubular biomaterials based on silk-PEO-blends with potential for microvascular grafts.

Source: Journal of Materials Chemistry B

DOI: 10.1039/c6tb02712a

Authors: V. E. Bosio, J. Brown, M. J. Rodriguez, D. L. Kaplan

Institutions: Tufts University, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de La Plata

Language: English

Topic: Silk-based biomaterials and applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: bronze

Funders: American Society for Biochemistry and Molecular Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering

Awards: G2951109674, G5894544799, G9000109527, Tissue Engineering Resource Center