Work

Tracking the formation of supramolecular G-quadruplexes via self-assembly enhanced emission

Year: 2016

Type: article

Abstract: We report the synthesis and self-assembly of two lipophilic 2'-deoxyguanosine (G) derivatives whose fluorescence intensity is modulated by self-assembly into supramolecular G-quadruplexes (SGQs). Whereas both derivatives self-assemble isostructurally, one shows up to 100% emission enhancement while the other shows an initial enhancement, followed by 10% quenching. Thus, the rotational restrictions resulting from self-assembly are enough to induce significant changes in emission, but it is critical to consider the specific interactions between fluorophores since they will determine the ultimate emission signature. These findings could open the door to the development of luminescent supramolecular sensors and probes.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/c6ob02586b

Authors: Diana Silva-Brenes, Loruhama Delgado, José M. Rivera

Institution: University of Puerto Rico at Río Piedras

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: Small Molecule Self-Assembly in Aqueos Media, Support for University Biomedical Excellence at UPR-RP