Work

321. Oncolytic Adenovirus Expressing IFN as a Tool To Eliminate Pancreatic Cancer Stem Cells

Year: 2015

Type: article

Abstract: Pancreatic cancer is the 4th leading cause of cancer related death in the US, and curative resection of tumors is the most effective treatment against the disease. Unfortunately, the majority of patients are diagnosed in the advanced stage of the disease, and palliative treatment with Gemcitabine is the therapy of choice. In both cases, curative resection of tumors or chemotherapy, effectiveness can be limited by the presence of pancreatic cancer stem cells. Cancer stem cells (CSC) are correlated with drug resistance, tumor recurrence, and metastasis.

Source: Molecular Therapy

DOI: 10.1016/s1525-0016(16)33930-2

Authors: Amanda R. Oliveira, Christopher J. LaRocca, Julia Davydova, Masato Yamamoto

Institution: University of Minnesota

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500