C-7. Adoptive Transfer of ZFN Mediated CCR5 Modified CD4 T-cells (SB-728-T) in HIV Subjects Leads to Long Term Engraftment of HIV Resistant T Memory Stem Cells and Decrease in Size of Latent Reservoir
Year: 2015
Type: article
Study design: Clinical Trial
Abstract: Background: Nine aviremic HIV+ subjects on ART with CD4 counts between 200-500 cells/mm3 received 10-30 billion SB-728-T cells. Sustained CD4 increases in peripheral blood (PB) were observed in all treated subjects (median +103 cells/mm3 at 1 year). CCR5-modified cells expanded and persisted (median = 1.6% in PB 3 years post infusion). Long-term persistence of CCR5-modified cells suggested their presence within long lived CD4 populations, such as central memory T-cells (TCM) and T memory stem cells (TSCM).
Source: Molecular Therapy
Authors: Joumana Zeidan, Gary Lee, Remy Fromentin, Jacob Lalezari, Ronald Mitsuyasu, Shelley Wang, Martin A. Giedlin, Geoff Nichol, Winson Tang, Nicholas Chomont, Dale Ando, Rafick-Pierre Sekaly
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W2561765813