Nickel‐Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms
Year: 2016
Type: article
Abstract: Two named reactions of fundamental importance and paramount utility in organic synthesis have been reinvestigated, the Barton decarboxylation and Giese radical conjugate addition. N ‐hydroxyphthalimide (NHPI) based redox‐active esters were found to be convenient starting materials for simple, thermal, Ni‐catalyzed radical formation and subsequent trapping with either a hydrogen atom source (PhSiH 3 ) or an electron‐deficient olefin. These reactions feature operational simplicity, inexpensive reagents, and enhanced scope as evidenced by examples in the realm of peptide chemistry.
Authors: Tian Qin, Lara R. Malins, Jacob T. Edwards, Rohan R. Merchant, Alexander J. E. Novak, Jacob Z. Zhong, Riley B. Mills, Ming Yan, Changxia Yuan, Martin D. Eastgate, Phil S. Baran
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2561830131