Work

CAR T‐cell therapy of solid tumors

Year: 2016

Type: review

Abstract: The potential for immunotherapy as a treatment option for cancer is clear from remarkable responses of some leukemia patients to adoptive cell transfer using autologous T cells genetically modified to express chimeric antigen receptors (CARs). However, the vast majority of cancers, in particular the more common solid cancers, such as those of the breast, colon and lung, fail to respond significantly to infusions of CAR T cells. Solid cancers present some formidable barriers to adoptive cell transfer, including suppression of T-cell function and inhibition of T-cell localization. In this review, we discuss the current state of CAR T-cell therapy in solid cancers, the variety of concepts being investigated to overcome these barriers as well as approaches aimed at increasing the specificity and safety of adoptive cell transfer.

Source: Immunology and Cell Biology

DOI: 10.1038/icb.2016.128

Authors: Carmen S M Yong, Valerie Dardalhon, Christel Devaud, Naomi Taylor, Phillip K Darcy, Michael H Kershaw

Institutions: Peter MacCallum Cancer Centre, Institut de Génétique Moléculaire de Montpellier, Institut de Recherche en Santé Digestive, Université de Toulouse

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Association pour la Recherche sur le Cancer, Cancer Therapeutics Cooperative Research Centre, Medical Research Council, National Health and Medical Research Council