Work

Effect of ethanol extract of plant mixture on hair regeneration in human dermal papilla cells and C57BL/6J mice

Year: 2015

Type: article

Abstract: This study determined the effect of 30% ethanol extract of plant mixture (EPM: Glycyrrhiza uralensis, Angelica gigas, Acorus calamus, Cnidium officinale, Panax ginseng, Camellia sinensis, Salvia miltiorrhiza, Zanthoxylum schinifolium, Carthamus tinctorius, Prunus persica and Scrophularia buergeriana) on promotion of hair growth in human hair dermal papilla cells and C57BL/6J mice. EPM significantly increased the proliferation of human hair dermal papilla cells in a dose- and time- dependent manner (p < 0.05 and p < 0.01). EPM also enhanced mRNA and protein levels of growth factors such as IGF-1, VEGF, KGF and HGF. Moreover, photographical and histological observation showed that application of EPM resulted in the early onset and prolongation of the anagen phase of the hair cycle. In addition, the EPM was revealed to possess potent inhibitory effect on the 5α-reductase activity. Taken together, these results suggest that EPM has hair growth promoting potential and can be used for hair growing products. Key words: Hair growth, extract of plant mixture, growth factors, steroid 5α-reductase.

Source: Journal of Medicinal Plants Research

DOI: 10.5897/jmpr2014.5355

Authors: Huang Bo, Kang Bueom Goo, Wang Zhiqiang, Sung Lim Soon

Institutions: Jinzhou Medical University, Hallym University

Language: English

Topic: Hair Growth and Disorders

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Research Foundation, National Research Foundation of Korea, Ministry of Education, Science and Technology