Work

Inhibition of mTORC1 signaling sensitizes hepatocellular carcinoma cells to glycolytic stress.

Year: 2016

Type: article

Abstract: . Meanwhile, genetic silencing several other downstream targets of mTORC1 signaling (TFEB, SREBP-1 and SKAR) failed to enhance or faintly influenced the cytotoxic effects of 2-DG. These results demonstrate that combining rapamycin with 2-DG holds significant promise as prospective clinical treatment in HCC.

Source: PubMed

Authors: Xin Zhao, Peng Jiang, Xiang Deng, Zhonghu Li, Feng Tian, Fei Guo, Xiaowu Li, Shuguang Wang

Institutions: Army Medical University, Southwest Hospital

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2562261475

FWCI: 1.152

Cites: 26

Cited by: 20

Related to: 10