Work

Modulators of IgG penetration through the blood-brain barrier: Implications for Alzheimer's disease immunotherapy

Year: 2016

Type: review

Abstract: This review serves to highlight approaches that may improve the access of antibody drugs to regions of the brain affected by Alzheimer's Disease. While previous antibody drugs have been unsuccessful in treating Alzheimer's disease, recent work demonstrates that Alzheimer's pathology can be modified if these drugs can penetrate the brain parenchyma with greater efficacy. Research in antibody blood-brain barrier drug delivery predominantly follows one of three distinct directions: (1) enhancing influx with reduced antibody size, addition of Trojan horse modules, or blood-brain barrier disruption; (2) modulating trancytotic equilibrium and/or kinetics of the neonatal Fc Receptor; and (3) manipulation of antibody glycan carbohydrate composition. In addition to these topics, recent studies are discussed that reveal a role of glycan sialic acid in suppressing antibody efflux from the brain.

Source: Human Antibodies

DOI: 10.3233/hab-160306

Authors: John M. Finke, William A. Banks

Institutions: University of Washington Tacoma, University of Washington, VA Puget Sound Health Care System

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2562304723

FWCI: 0.087

Cites: 164

Cited by: 23

Related to: 10