HMGB-1 Release and the CD8+ T Cell Response Elicited by Radiation Treatment in Malignant Pleural Mesothelioma
Year: 2015
Type: dissertation
Abstract: Malignant pleural mesothelioma (MPM) is a cancer of the pleura that is associated with the inhalation of asbestos. Treatments, such as radiation therapy, have direct cytotoxic effects on cancer cells in addition to immune activating effects through the release of pro-inflammatory molecules associated with cancer cell death. The goal of this project was to investigate the role of High Mobility Group Box 1 (HMGB-1), a typical Danger Associated Molecular Pattern (DAMP) protein released after radiation treatment, in CD8+ T Cell mediated tumor killing and in patient survival. Radiated tumor cells release HMGB-1 in vitro. Furthermore, radiation treatment leads to HMGB-1 release and correlates with higher survival in vivo. This thesis demonstrates that radiation leads to HMGB-1 release which is correlated to MPM cell death and increased survival in vivo. The findings of this project could be used to develop new therapies in combination with radiation.
Source: TSpace (University of Toronto)
Author: Matthew Wu
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2562378008