Year: 2016
Type: article
Abstract: In this issue of Blood, Antonelli et al1 developed a novel xenograft mouse model that mimics a humanized bone marrow (BM) niche that improved human leukemia engraftment and promoted growth and clonal diversity. This new approach is the next step in decades of work to recapitulate leukemia development and growth in mice: from initial studies using syngeneic murine leukemia cell lines; then, engineering transgenic mice or hematopoietic stem cells for expression of leukemia oncogenes; and, more recently, using a variety of permissive immune-deficient mouse strains that support robust xenografting with primary human leukemia samples.
Source: Blood
Author: Renata Stripecke
Institution: Medizinische Hochschule Hannover
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2562631547