Work

18F-FDG and 68Ga-DOTATATE PET/CT in von Hippel-Lindau Disease–Associated Retinal Hemangioblastoma

Year: 2016

Type: article

Abstract: Retinal hemangioblastomas are highly vascular benign tumors that can be encountered either sporadically or within the von Hippel-Lindau (VHL) syndrome. We report a case of a VHL patient with retinal hemangioblastoma who underwent PET/CT scans using F-FDG and Ga-DOTATATE. The tumor showed low-level F-FDG and increased Ga-DOTATATE activity, suggesting cell-surface overexpression of somatostatin receptors. The presented case indicates the clinical applications of somatostatin receptor imaging with Ga-DOTA-conjugated peptides in detection and follow-up of VHL manifestations, screening of asymptomatic gene carriers, and in diagnosis of sporadic retinal hemangioblastomas, which may have similar features on MRI with other retinal tumors.

Source: Clinical Nuclear Medicine

DOI: 10.1097/rlu.0000000000001511

Authors: Georgios Z. Papadakis, Corina Millo, Inderbir S. Jassel, Ulas Bagci, Samira M. Sadowski, Apostolos H. Karantanas, Nicholas J. Patronas

Institutions: University of Central Florida, University of Geneva, National Institutes of Health, University of Crete, University Hospital of Geneva, National Cancer Institute, National Institutes of Health Clinical Center, University of Leeds

Language: English

Topic: Ocular Oncology and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2562739530

FWCI: 1.417

Cites: 13

Cited by: 22

Related to: 10