Work

8. Guanylyl Cyclase A-Targeted Gene Therapy Ameliorates Disease Progression in Autosomal Recessive Polycystic Kidney Disease

Year: 2015

Type: article

Abstract: Although Polycystic Kidney Disease (PKD) is a leading cause of renal and hepatic pathologies, there are limited therapies available. PKD presents with cystic manifestations leading to organ enlargement, loss of functional parenchyma, progressive organ dysfunction and hypertension, ultimately leading to organ failure.

Source: Molecular Therapy

DOI: 10.1016/s1525-0016(16)33612-7

Authors: Sara J. Holditch, Alessandro Cataliotti, Vicente Torres, Yasuhiro Ikeda

Institution: Mayo Clinic

Language: English

Topic: Genetic and Kidney Cyst Diseases

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500