Year: 2016
Type: article
Study designs: Systematic Review, Meta-Analysis
Abstract: The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3,129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P<0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16/18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P<0.0001). There was no statistically significant difference in HPV16/18 prevalence in non-oropharyngeal cancer by race (P=0.682). With regard to the pattern of HPV16/18 status and p16 expression, White patients had the highest proportion of HPV16/18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0% and 22.6%, respectively) [P <0.0001]. Our findings suggest that the pattern of HPV16/18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.
Source: Carcinogenesis
Authors: Camille Ragin, Jeffrey C. Liu, Gieira Jones, Olubunmi Shoyele, Bukola Sowunmi, Rachel Kennett, Denise Gibbs, Elizabeth Blackman, Michael Esan, Margaret S. Brandwein, Karthik Devarajan, Francesco Bussu, Rebecca Chernock, Chih-Yen Chien, Marc A. Cohen, Samir El-Mofty, Mikio Suzuki, Gypsyamber D’Souza, Pauline Funchain, Charis Eng, Susanne M. Gollin, Angela Hong, Yuh-S Jung, Maximilian Krüger, James Lewis, Patrizia Morbini, Santo Landolfo, Massimo Rittà, Jos Straetmans, Krisztina Szarka, Ruth Tachezy, Francis P. Worden, Deborah Nelson, Samuel Gathere, Emanuela Taioli
Institutions: Fox Chase Cancer Center, Temple University, Western Connecticut Health Network, Danbury Hospital, University at Buffalo, State University of New York, Università Cattolica del Sacro Cuore, Agostino Gemelli University Polyclinic, Washington University in St. Louis, Chang Gung University, Kaohsiung Chang Gung Memorial Hospital, Memorial Sloan Kettering Cancer Center, University of the Ryukyus, Johns Hopkins University, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, University of Pittsburgh, The University of Sydney, National Cancer Center, Johannes Gutenberg University Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Vanderbilt University, University of Pavia, Policlinico San Matteo Fondazione, University of Turin, Maastricht University Medical Centre, University of Debrecen, Institute of Haematology and Blood Transfusion, University of Michigan, Michigan Medicine, Kenya Medical Research Institute, Icahn School of Medicine at Mount Sinai
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2562865704