Work

Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability

Year: 2016

Type: article

Abstract: Successful cell proliferation requires efficient and precise genome duplication followed by accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is required for the first step in DNA replication, and in human cells Cdt1 is also required during mitosis. Tight cell cycle controls over Cdt1 abundance and activity are critical to normal development and genome stability. We review here recent advances in elucidating Cdt1 molecular functions in both origin licensing and kinetochore-microtubule attachment, and we describe the current understanding of human Cdt1 regulation.

Source: Genes

DOI: 10.3390/genes8010002

Authors: Pedro Pozo, Jeanette Cook

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,137

Funders: W. M. Keck Foundation, National Institutes of Health, National Institute of General Medical Sciences