Year: 2015
Type: article
Abstract: CARs have shown great promise in the field of targeted immunotherapy against cancer. These serve as a powerful tool that help redirect T cells to recognize and target tumor cells. Despite extensive clinical testing, the underlying attributes that ensure optimal T cell survival and effector functions are yet to be delineated. Here we analyze the effects of different signaling domains on the proliferation and function of CAR T cells. We report how different CAR costimulatory domains can affect cell longevity.
Source: Molecular Therapy
Institutions: University of Pennsylvania, Abramson Cancer Center
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W2562919329