Work

Directional Fluid Transport across Organ–Blood Barriers: Physiology and Cell Biology

Year: 2016

Type: preprint

Abstract: Directional fluid flow is an essential process for embryo development as well as for organ and organism homeostasis. Here, we review the diverse structure of various organ-blood barriers, the driving forces, transporters, and polarity mechanisms that regulate fluid transport across them, focusing on kidney-, eye-, and brain-blood barriers. We end by discussing how cross talk between barrier epithelial and endothelial cells, perivascular cells, and basement membrane signaling contribute to generate and maintain organ-blood barriers.

Source: Cold Spring Harbor Perspectives in Biology

DOI: 10.1101/cshperspect.a027847

Authors: Paulo S. Caceres, Ignacio Benedicto, Guillermo L. Lehmann, Enrique J. Rodriguez-Boulan

Institution: Weill Cornell Medicine

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

Open Access status: bronze