Work

297. Sensitivity and Mechanisms of Resistance of Human Induced Pluripotent Stem Cells To the Inducible Caspase-9 Safety Switch

Year: 2015

Type: article

Abstract: Introduction of inducible caspase-9 suicide gene (iC9) is one of the most appealing safety strategies for the cell therapy. iC9-mediated cell death is produced by direct activation of the pro-apoptotic molecule in the downstream portion of the intrinsic apoptotic pathway, so that potent and rapid killing is observed in the presence of the chemical inducer of dimerization (CID). To control the cell fate of human induced pluripotent stem cells (hiPSC) and minimize the possible unwanted effect of therapies using hiPSC, we produced hiPSC that expressed the iC9 safety system.

Source: Molecular Therapy

DOI: 10.1016/s1525-0016(16)33906-5

Authors: Shigeki Yagyu, Malcolm K. Brenner

Institution: Baylor College of Medicine

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500