Work

141. Combinatorial Aptamer Transcripts (CATs) for HIV RT Suppression

Year: 2015

Type: article

Abstract: The Human Immunodeficiency Virus (HIV) Reverse Transcriptase (RT) is a DNA polymerase encoded by the viral genome and it is preferentially targeted by current therapeutics due to its critical role in the viral life cycle. High affinity RNA aptamers that bind RT out-compete viral genome for access to the active site and thereby inhibit replication. Aptamer binding to RT during viral formation is believed to drive aptamer encapsidation into the budding virus, which leads to significantly reduced infectivity.

Source: Molecular Therapy

DOI: 10.1016/s1525-0016(16)33746-7

Authors: Kyle J. Hill, Margaret J. Lange, Donald H. Burke

Institution: University of Missouri

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500