Get started
Work

311. AAV8 Vexosome Vectors Enhance Cell Transduction In Vitro and Outperform Conventional AAV8 Vectors in Liver-Transduction In Vivo in the Presence of Anti-AAV Neutralizing Antibodies

Year: 2015
Type: article
Abstract: Adeno-associated virus vectors based on serotype 8 (AAV8) have demonstrated superior efficiency of transduction of hepatocytes in vivo in animal models and in humans. Recently, we described extracellular vesicle (exosomes) -associated AAV vectors termed vexosomes (vAAV). We tested vAAV1, 2, and 9 and found them to enhance transduction and antibody evasion capabilities compared to conventional AAV vectors.
DOI: 10.1016/s1525-0016(16)33920-x
Authors: Amine Meliani, Zachary Fitzpatrick, Severine Charles, Dakai Mu, Florence Boisgerault, Casey A. Maguire, Federico Mingozzi
Language: English
Subfield: Genetics
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W2563210205
FWCI:
Cites:
Cited by:
Related to: 10