Year: 2017
Type: review
Abstract: An understanding of the events that initiate metabolic inflammation (metainflammation) can support the identification of targets for preventing metabolic disease and its negative effects on health. There is ample evidence demonstrating that the initiating events in obesity-induced inflammation start early in childhood. This has significant implications on our understanding of how early life events in childhood influence adult disease. In this Review we frame the initiating events of metainflammation in the context of child development and discuss what this reveals about the mechanisms by which this unique form of chronic inflammation is initiated and sustained into adulthood.
DOI: 10.1172/jci88882
Authors: Kanakadurga Singer, Carey N. Lumeng
Institutions: University of Michigan, Michigan Medicine
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: American Diabetes Association, University of Michigan, National Institutes of Health, College of Pharmacy, University of Michigan, Medical School, University of Michigan, National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1623809436, Mechanisms of hematopoietic stem cell activation in obesity, G2351744653, Regulation of Adipose Tissue Inflammation By Antigen Presenting Cells, The Impact of Postnatal Overnutrition on the Adipose Tissue Immune System and Metabolic Inflammation, Michigan Diabetes Research Center (MDRC)
OpenAlex ID: W2563391368