Work

AMPK-mediated cardioprotection of atorvastatin relates to the reduction of apoptosis and activation of autophagy in infarcted rat hearts.

Year: 2016

Type: article

Abstract: <0.05). The treatment also inhibited induction of pro-apoptotic protein Bax. AMPK inhibitor Compound C reversed these beneficial effects. In conclusion, ATV improves survival of cardiomyocytes and decreases alterations in morphology and function of infarcted hearts by inducing autophagy and inhibiting apoptosis through the activation of AMPK/mTOR pathway.

Source: PubMed Central

Authors: Qing Li, Qiu-Ting Dong, Yue-Jin Yang, Xia-Qiu Tian, Chen Jin, Pei-Sen Huang, Lei-Pei Jiang, Gui-Hao Chen

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease

Language: English

Topic: Cardiac Ischemia and Reperfusion

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Alcohol Abuse and Alcoholism

Award: Impact of Prenatal Alcohol Exposure on Receptor Targeting and Functioning

OpenAlex ID: W2563393674

FWCI: 2.64

Cites: 46

Cited by: 34

Related to: 10