Individualized Tamoxifen Dose Escalation—Response
Year: 2016
Type: article
Abstract: We thank Koolen and colleagues for their thoughtful response to our commentary about the lack of evidence supporting tamoxifen dose escalation based on predicted or measured endoxifen concentrations (1). They state that “if the concentration has been measured and it is far below the currently adopted minimum value for efficacy of approximately 6 ng/mL, we feel it is unethical not to intervene and not trying to increase the exposure.” The critical phrase in their assertion is “if the concentration has been measured,” whereas in our commentary, we take the position that endoxifen concentrations should not be measured given the current lack of evidence supporting this approach.The authors posited that breast cancer patients taking tamoxifen could benefit from systemic endoxifen concentration measurements. As clinical pharmacologists, we agree that patients with lower drug concentrations may experience inferior therapeutic effectiveness; however, there is an established translational pathway for biomarker hypotheses. The two critical steps are: (i) confirming that the biomarker is associated with a treatment outcome (“clinical validity”) and (ii) demonstrating that biomarker collection improves a treatment outcome (“clinical utility”). Currently, there are a large number of biomarkers being tested that may someday prove to benefit patients, including measurement of drug concentrations and various physiologic “pharmacodynamics” indicators, such as systemic estradiol concentrations in breast cancer patients receiving aromatase inhibitors. However, it is incumbent upon translational researchers to document the biomarker's clinical validity and utility prior to adoption into clinical practice.Koolen and colleagues refer to a “minimum value for efficacy of approximately 6 ng/mL” for circulating endoxifen concentrations and cite a single retrospective study reporting this threshold. Our commentary noted two prospective clinical trials investigating the putative association between endoxifen concentration and tamoxifen treatment efficacy, neither of which confirmed clinical validity in preliminary results reported at ASCO 2016 (2, 3).In this era of unsustainably increasing health care costs, particularly in cancer treatment, it is critical to practice evidence-based medicine. Given the lack of evidence of clinical validity or utility, measuring endoxifen concentrations is practicing one of the alternatives to evidence-based medicine (4). If endoxifen concentration has been measured and found to be low, increasing the tamoxifen dose would be reasonable based on the documented safety of this approach (5) and could potentially enhance efficacy. However, an endoxifen threshold for efficacy has not been established and, at least until one is, clinicians should not measure endoxifen concentration to inform personalized tamoxifen treatment decisions.See the original Letter to the Editor, p. 6300No potential conflicts of interest were disclosed.
Source: Clinical Cancer Research
Authors: Daniel L. Hertz, James M. Rae
Institutions: University of Michigan, Michigan Medicine
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
Award: G4631666213
OpenAlex ID: W2563413387