Disturbed Object Processing in 5xFAD and 3xTG Mouse Models of Alzheimer's Disease: Going Beyond "Object Recognition"
Year: 2016
Type: dissertation
Abstract: Object recognition not a unitary process, and there are many uncharacterized facets of object processing that have relevance to Alzheimer’s disease (AD). To elucidate the specific nature of object processing deficits in transgenic mouse models of AD, we systematically evaluated performance on tasks that manipulate different types of object information: object identity (i.e., object recognition: OR), spatial processing (object location; OL), temporal processing (temporal order; TO), and multisensory perception (multisensory object oddity; MSO) in 12-month-old male and female 5xFAD and 3xTG mice. 5xFAD mice were impaired on OR, OL, TO and MSO. Conversely, 3xTG females had intact short-term OR, and when spatial cues were minimized both males and females had intact short-term OR. 3xTG mice had impaired OL, TO and MSO. Results reveal dissociations across AD strain, sex, and type of object processing, and should help to clarify the relationship between specific aspects of AD pathology and object-related information processing.
Author: Samantha D. Creighton
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2563559268