Work

Redox‐Activated Signal Transduction Pathways Mediating Cellular Functions in Inflammation, Differentiation, Degeneration, Transformation, and Death

Year: 2016

Type: editorial

Abstract: The early atmosphere of the earth contained low concentration of oxygen, which then slowly initiated to increase approximately 2.5 billion years ago after development of photosynthetic organisms and reached life-supporting levels 500–1000 million years ago. According to the oxygenic theory of evolution even the most primitive organisms used oxidative-antioxidative mechanisms in energy production, hence underlining the importance of reactive oxygen species (ROS) in normal cellular functions [1]. In reduction-oxidation (redox) biology the balance of oxidants and antioxidants determines the normal cellular homeostasis that is altered in tissue injuries and pathological conditions. Therefore, ROS, or unbalanced production of ROS, are often a consequence of injury or pathological condition with corresponding impact on cellular signal transduction and damage to macromolecules. The focus of this special issue is to characterize signaling pathways involved in tissue pathogenesis. Such studies potentially result in drug targets that supplement targets observed in currently used screenings [2].

Source: Oxidative Medicine and Cellular Longevity

DOI: 10.1155/2016/8479718

Authors: Tetsuro Kamiya, Michael Courtney, Mikko O. Laukkanen

Institutions: Gifu Pharmaceutical University, University of Turku, Turku Centre for Biotechnology

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680