Work

677. Evaluation of Tumor Specific Promoters for Use in Conditionally Replicating Adenovirus Mediated Virotherapy of Canine Lymphoma

Year: 2016

Type: article

Abstract: Conditionally Replicating Adenoviruses (CRAds) are genetically modified therapeutic viruses that incorporates transcriptional targeting of replication to promote selective killing of tumor cells. Transcriptional targeting utilizes tissue/tumor-specific promoters driving the expression of genes in a tissue- or tumor-specific manner to allow replication of the virus in tumor cells while sparing normal cells. Selection of appropriate intermediate animal models is a basic-requirement for successful cancer virotherapy.

Source: Molecular Therapy

DOI: 10.1016/s1525-0016(16)33485-2

Authors: Abdul Mohin Sajib, Samantha Morici, Maninder Sandey, Payal Agarwal, Bruce Smith

Institution: Auburn University

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500