Year: 2016
Type: review
Abstract: Peripheral nerve injury can lead to great morbidity in those afflicted, ranging from sensory loss, motor loss, chronic pain, or a combination of deficits. Over time, research has investigated neuronal molecular mechanisms implicated in nerve damage, classified nerve injury, and developed surgical techniques for treatment. Despite these advancements, full functional recovery remains less than ideal. In this review, we discuss historical aspects of peripheral nerve injury and introduce nerve transfer as a therapeutic option, as well as an adjunct therapy to transplantation of Schwann cells and their stem cell derivatives for repair of the damaged nerve. This review furthermore, will provide an elaborated discussion on the sources of Schwann cells, including sites to harvest their progenitor and stem cell lines. This reflects the accessibility to an additional, concurrent treatment approach with nerve transfers that, predicated on related research, may increase the efficacy of the current approach. We then discuss the experimental and clinical investigations of both Schwann cells and nerve transfer that are underway. Lastly, we provide the necessary consideration that these two lines of therapeutic approaches should not be exclusive, but conversely, should be pursued as a combined modality given their mutual role in peripheral nerve regeneration.
DOI: 10.3390/ijms17122101
Authors: Robert Sullivan, Travis Dailey, Kelsey Duncan, Naomi Abel, Cesario Borlongan
Institution: University of South Florida
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,499
Awards: Blood-Brain Barrier Repair in Cell Therapy for Stroke, BATTLEFIELD-RELATED INJURY TRANSLATIONAL RESEARCH, POST-TRAUMATIC DISEASE AND DISABILITY-VETERANS RE-INTEGRATION STRATEGY, G3780238105, G4119534169, Vascular repair extends therapeutic window for ischemic stroke, G5850682332, Re-Establishing Vascular Integrity in ALS via Endothelial Cell Transplant
OpenAlex ID: W2564642936