Work

Regulation of Group I Metabotropic Glutamate Receptors by MAPK/ERK in Neurons.

Year: 2016

Type: article

Abstract: . Association of ERK with mGluR1/5 enables the kinase to phosphorylate mGluR1/5 at a cluster of serine sites in the distal C terminus, including a serine residue within the Homer binding site. The ERK-mediated phosphorylation of mGluR1/5 promotes surface expression of mGluR1a in cerebellar neurons. ERK also regulates mGluR1/5 signaling and functions. Among different functional outputs surveyed, ERK exerts an output-specific role in either potentiating or inhibiting their activities. In sum, synaptic group I mGluRs are sufficient substrates of MAPK/ERK. Phosphorylation of mGluR1/5 by ERK has a significant impact on subcellular expression and function of phospho-modified receptors.

Source: PubMed

Authors: Li-Min Mao, John Q Wang

Institution: University of Missouri–Kansas City

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Institute of Mental Health, National Institute on Drug Abuse

Awards: Molecular Regulation of Metabotropic Glutamate Receptors in Striatal Neurons, Metabotropic Glutamate Regulation of Amphetamine Action, METABOTROPIC GLUTAMATE REGULATION OF AMPHETAMINE ACTION

OpenAlex ID: W2564721815

FWCI: 1.252

Cites: 44

Cited by: 17

Related to: 10