Work

Protein kinase Cι: A versatile oncogene in the lung

Year: 2016

Type: editorial

Abstract: We have recently demonstrated that protein kinase Cι (PKCι) promotes a stem-like, tumor-initiating cell phenotype in KRAS-driven lung adenocarcinoma by activating a novel ELF3-NOTCH3 signaling axis.Citation1 Combined PKCι and NOTCH inhibition was identified as a novel strategy for the treatment of KRAS-driven lung adenocarcinoma.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2016.1190886

Authors: Alan P. Fields, Syed A. Ali, Verline Justilien, Nicole R. Murray

Institutions: Mayo Clinic in Florida, Mayo Clinic Comprehensive Cancer Center (Florida)

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, Center for Individualized Medicine, Mayo Clinic, National Cancer Institute