Variation in Nicotine and Nitrosamine Pharmacology Genes and Smoking-associated Lung Cancer
Year: 2015
Type: dissertation
Abstract: Lung cancer is the leading cause of death from cancer in North America. While the vast majority of lung cancer cases are attributable to cigarette smoke exposure, among smokers there are substantial differences in the risk for lung cancer even taking into account cigarettes per day and years of smoking. Identifying and characterizing genetic factors that influence the relationship between smoking and lung cancer continues to be a priority. Among the thousands of chemicals in cigarette smoke, nicotine is critical in establishing and maintaining smoking behaviours, while nitrosamines are an important class of carcinogens that require metabolic processing by the body to exert their full carcinogenicity. Owing to the structural similarities between nicotine and nitrosamines, these chemicals interact with many of the same enzymes and receptors in the body. We demonstrate that genetic variation in the nicotine/nitrosamine metabolizing genes,
Source: TSpace (University of Toronto)
Author: Catherine A. Wassenaar
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2564843493