Work

What Drives Positive Selection in the Drosophila piRNA Machinery? The Genomic Autoimmunity Hypothesis.

Year: 2016

Type: article

Abstract: species. We propose that recurrent positive selection in the piRNA machinery can be partly explained by an ongoing tension between selection for sensitivity required by genome defense and selection for specificity to avoid the off-target effects of maladaptive genic silencing by piRNA.

Source: Europe PMC (PubMed Central)

Authors: Justin P Blumenstiel, Alexandra A Erwin, Lucas W Hemmer

Institution: University of Kansas

Language: English

Topic: Chromosomal and Genetic Variations

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2565046831

FWCI: 1.596

Cites: 96

Cited by: 39

Related to: 10