Year: 2013
Type: article
Abstract: Antisense transcription is omnipresent occurring broadly in most living organisms.Growing evidence suggests the presence of noncoding cis-antisense RNA's that can silence gene expression.Recent studies also indicate the role of transcriptional interference in regulating expression of neighboring genes arranged in convergent orientation.A combination of transcriptional interference and cis-antisense RNA interaction has the potential to add multiple-levels of regulation which can allow such a system to have a tunable and complex higher-order system response to environmental stimuli.This presents an important insight into the functional role of antisense transcription. Antisense RNAs and RNA Interaction Mechanisms in Bacteriacis-Antisense RNA is produced when transcription occurs from the DNA strand opposite to a transcriptional unit (Figure 1a-c).cis-Antisense RNA's tend to overlap either at the 5′ end (head to head overlap), such as the prgQ/prgX gene pair of E. faecalis [32], MgtC/ AmgR sense antisense pair in S. enterica [49], hok/sok toxin-antitoxin system in E. coli [50]; or at the 3′ end (tail to tail overlap), such as in the case of alr1690, which overlaps the adjacent gene all1691 gene
Source: Journal of Gene Therapy
Authors: Colleen M. Courtney, Anushree Chatterjee
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
Funder: National Institutes of Health
OpenAlex ID: W4213243977