Work

LncRNA CRNDE promotes hepatic carcinoma cell proliferation, migration and invasion by suppressing miR-384.

Year: 2016

Type: article

Abstract: . Quantitative real-time polymerase chain reaction (PCR) demonstrated that miR-384 was significantly downregulated in HCC tissues. Moreover, we indicated CRNDE negatively regulated miR-384 expression in HCC. In addition, we found that CRNDE accelerated the expression levels of NF-κB and p-AKT though inhibition of miR-384. Overall, these results suggested that CRNDE-miR-384 axis might be a promising therapeutic target for the treatment of HCC.

Source: PubMed

Authors: Zili Chen, Chao Yu, Lei Zhan, Yaozhen Pan, Ling Chen, Chengyi Sun

Institution: Affiliated Hospital of Guizhou Medical University

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2565206604

FWCI: 7.176

Cites: 33

Cited by: 114

Related to: 10