Work

Accessing alternative reaction pathways of the intermolecular condensation between homo-propargyl alcohols and terminal alkynes through divergent gold catalysis

Year: 2017

Type: article

Abstract: , an efficient Au-catalyzed cyclization-alkynylation strategy furnishes (2-arylalkynyl) cyclic ethers in moderate to excellent yields (up to 94%). This strategy is extended to the synthesis of functionalized 2,3-dihydrooxepines via the sequential Au-catalyzed ring expansion of the cyclic ether substrates.

Source: Chemical Communications

DOI: 10.1039/c6cc09794d

Authors: Courtney A. Smith, Stephen E. Motika, Lukasz Wojtas, Xiaodong Shi

Institution: University of South Florida

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Natural Science Foundation of China, National Institutes of Health, National Institute of General Medical Sciences

Awards: G1927317889, G4549635901, G6622831452, Achieving challenging coupling with gold redox catalysis