Work

526. Specific Companion Cells Enhance the Engraftment of Ex-Vivo Expanded HSCs (CD34 + /CD38 − /CD90+)

Year: 2016

Type: article

Abstract: Efforts to expand in vitro the number of engraftable hematopoietic stem cells (HSCs) for transplantation, is an ongoing quest in stem cell biology. Success in this endeavor is critical for increasing insufficient donor cells for transplantation and/or for the in vitro manipulation of autologous stem cells in gene therapy approaches. Recent studies have revealed that a number of novel small molecules can efficiently enhance the HSC-like phenotype of cultured cells with Stem Regenin1 (SR1) and UM171 showing the most promising outcomes.

Source: Molecular Therapy

DOI: 10.1016/s1525-0016(16)33335-4

Authors: Nikoleta Psatha, Thalia Papayannopoulou

Institution: University of Washington

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500