59. Multiplex Gene Activation by CRISPR/Cas9-Based Transcription Factors for the Direct Conversion of Fibroblasts to a Neuronal Phenotype
Year: 2015
Type: article
Abstract: The reprogramming of cell lineage between mature somatic cell types has a significant potential to advance disease modeling, drug discovery, and gene and cell therapies for regenerative medicine. Several groups have established methods to reprogram cell phenotype through the ectopic delivery of cDNAs encoding master regulatory transcription factors. These factors can target epigenetically silenced genes and activate transcriptional networks specific to other cell lineages.
Source: Molecular Therapy
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W2566087572