Year: 2015
Type: letter
Abstract: Yu et al.1 investigated the association of TMEM106B variants with TAR-DNA binding protein 43 (TDP-43) pathology in elderly individuals without frontotemporal lobar degeneration (FTLD-TDP). They also examined whether these associations were independent of comorbid pathologic processes, such as Alzheimer disease (AD) and hippocampal sclerosis (HS). The results confirmed earlier findings that TMEM106B variants are an important TDP-43 pathology risk factor in FTLD-TDP, sporadic amyotrophic lateral sclerosis, AD, tangle predominant dementia, and Lewy body disease.2,–,4 The …
Source: Neurology
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: National Institute on Aging
Awards: Epidemiologic Study of Neural Reserve and Neurobiology of Aging, Epidemiologic Study of TDP-43 Pathology in Aging and Dementia, Risk Factors, Pathology, and Clinical Expressions of AD, Rush Alzheimer's Disease Core Center, Risk Factors, Pathology, and Clinical Expressions of AD, Exploring the Role of the Brain Epigenome: Cognitive Decline and Life Experiences
OpenAlex ID: W2566484333