Work

Repeated Administration of Mercury Intensifies Brain Damage in Multiple Sclerosis through Mitochondrial Dysfunction.

Year: 2016

Type: article

Abstract: In this study we investigated the additive effect of mercury on the brain mitochondrial dysfunction in experimental autoimmune encephalomyelitis (EAE) model. Experimental animals (female C57BL/6 mice) are divided into four groups (n = 8); control, Hg, EAE, EAE with Hg. EAE model of MS induced by injecting myelin oligodendrocyte glycoprotein (MOG). Neurobehavioral alterations are recorded and then mice were sacrificed at day 28 and brain mitochondria were isolated and mitochondrial toxicity parameters including mitochondrial swelling, reactive oxygen species (ROS) formation, collapse of mitochondrial membrane potential (MMP) and cytochrome c release were measured. Our results showed that repeated treatment of mercury following induction of EAE in mice significantly increased the neurobehavioral scores, as well as mitochondrial toxicity through ROS formation, mitochondrial swelling, collapse of MMP and cytochrome c release. Our findings proved that repeated exposure with mercury accelerates progression of MS through mitochondrial damage related to oxidative stress and finally apoptosis.

Source: PubMed Central

Authors: Farzad Kahrizi, Ahmad Salimi, Farshid Noorbakhsh, Mehrdad Faizi, Freshteh Mehri, Parvaneh Naserzadeh, Nima Naderi, Jalal Pourahmad

Institutions: Shahid Beheshti University, Shahid Beheshti University of Medical Sciences, Ardabil University of Medical Sciences, Tehran University of Medical Sciences

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Iran National Science Foundation, Shahid Beheshti University of Medical Sciences

OpenAlex ID: W2566587886

FWCI: 1.327

Cites: 20

Cited by: 23

Related to: 10