Work

MicroRNA‐335‐5p and ‐3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance

Year: 2016

Type: article

Abstract: microRNAs (miRNAs) are small noncoding RNA molecules involved in the regulation of gene expression and play critical roles in human malignancies. Next-generation sequencing analysis of the MCF-7 breast cancer cell line overexpressing miR-335-5p and miR-335-3p demonstrated that the miRNA duplex repressed genes involved in the ERα signaling pathway, and enhanced resistance of MCF-7 cells to the growth inhibitory effects of tamoxifen. These data suggest that despite its conventional role in tumor suppression, the miR-335 transcript can also play an oncogenic role in promoting agonistic estrogen signaling in a cancerous setting.

Source: FEBS Letters

DOI: 10.1002/1873-3468.12538

Authors: Elizabeth C. Martin, Adrienne K. Conger, Thomas J. Yan, Van T. Hoang, David F. B. Miller, Aaron Buechlein, Douglas B. Rusch, Kenneth P. Nephew, Bridgette M. Collins‐Burow, Matthew E. Burow

Institutions: Louisiana State University, Louisiana State University Agricultural Center, Vanderbilt University Medical Center, Tulane University, Indiana University Bloomington, Indiana University School of Medicine, Indiana University

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, Office of Naval Research, National Cancer Institute, National Institute of General Medical Sciences, National Center for Research Resources, National Institute on Minority Health and Health Disparities

Awards: G1338581810, G1629864115, G1937633654, G3008678950, G4371657964, G5673037914, G8373636068, G9000152507, G9000259285, Louisiana Clinical and Translational Science Center

OpenAlex ID: W2566955250

FWCI: 2.183

Cites: 45

Cited by: 48

Related to: 10