Work

421. Evaluating the Efficacy of Combination Cancer Treatment: Oncolytic Adenovirus and 5FU Chemotherapy

Year: 2016

Type: article

Abstract: Previous studies have shown that Interferon(IFN)-based chemoradiation therapy can improve survival after resection of pancreas cancer. However, its clinical utility to this point has been limited due to the severe toxicity related to its use systemically. Gene Therapy represents a promising approach to deliver localized treatments that are effective and minimally toxic. Our aim in this study is to evaluate our group's novel oncolytic adenovirus (OAd) which allows targeting IFN treatment to cancer cells while sparing healthy tissue.

Source: Molecular Therapy

DOI: 10.1016/s1525-0016(16)33230-0

Authors: Jordan Sell, Amanda Oliviera, Eric Jensen, Edward Greeno, Masato Yamamoto, Julia Davydova

Institution: University of Minnesota

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500