Fatty acid metabolism and metabolic inflammation : two important players in the development of insulin resistance
Year: 2013
Type: dissertation
Abstract: The metabolic syndrome is a multi-component condition that includes obesity hypertriglyceridemia and insulin resistance. The prevalence of the metabolic syndrome is rising world-wide and is associated with an increased risk for the development of cardiovascular diseases and type 2 diabetes. In the past decades it has been discovered that obese persons have slightly elevated markers of inflammation in their plasma. This low-grade chronic inflammation, also called metabolic inflammation, is hypothesized to function as the link between the various components of the metabolic syndrome. In this thesis, it is evaluated how alterations in triglyceride (TG) and fatty acid (FA) metabolism and inflammatory pathways interact in the development of obesity and insulin resistance, which are both primary risk factors for the development of type 2 diabetes
Author: Irene O.C.M. Vroegrijk
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2568024692