Year: 2017
Type: article
Abstract: Even though T-cell receptor (TCR) stimulation together with co-stimulation is sufficient for the activation of both naïve and memory T cells, the memory cells are capable of producing lineage specific cytokines much more rapidly than the naïve cells. The mechanisms behind this rapid recall response of the memory cells are still not completely understood. Here, we performed epigenetic profiling of human resting naïve, central and effector memory T cells using ChIP-Seq and found that unlike the naïve cells, the regulatory elements of the cytokine genes in the memory T cells are marked by activating histone modifications even in the resting state. Therefore, the ability to induce expression of rapid recall genes upon activation is associated with the deposition of positive histone modifications during memory T cell differentiation. We propose a model of T cell memory, in which immunological memory state is encoded epigenetically, through poising and transcriptional memory.
Source: Scientific Reports
DOI: 10.1038/srep39785
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Advancing Translational Sciences
Awards: Role of Chromatin and Gene Poising in T Cell Differentiation and Activation, Center for Clinical and Translational Science and Training, G5520316217, Direct Epigenetic Reprogramming of T Cells, Epigenetic reprogramming by nickel through chromatin domain disruption, Epigenetic Dysregulation by Oxidative Stress from Environmental Insults, G8245670873, G9000295917, Cincinnati Rheumatic Diseases Resource Center, Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease
OpenAlex ID: W2569270101